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Domenico Ghirlandaio was born in Florence in 1449.
He created a workshop in which students Michelangelo and Francesco Granacci.
In 1475, Domenico Ghirlandaio was called to Rome. He is chosen, with his brother David, to paint the frescoes in the library of Sixtus IV in the Vatican Palace.
He painted twelve figures of the ancient philosophers (Aristotle, Antisthenes, Cleobulus, Diogenes, Plato and Socrates) and the Church Fathers (St. Ambrose, St. Augustine, St. Bonaventure, St. Gregory, St. Jerome and St. Thomas Aquinas) .
In 1481 he was selected with Botticelli, Perugino and Rosselli to decorate the Sistine Chapel.
In 1492, he painted the frescoes in the hall of the Palazzo Vecchio Lys Florence and those of the Sassetti family chapel in Santa Trinita in Florence.
An altarpiece representing the Visitation is visible in the Louvre in Paris.
He died of fever in January 1494.